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疼痛与炎症研究

(五合一)痛觉测量系统

时间:2016-09-15来源:本站作者:玉研仪器

详细介绍

五合一痛觉测量系统

we has developed the first commercially available unit that has the capability of performing four individual tests with one unit.


  • electronic von frey anesthesiometer 电子von frey测痛仪

  • randall selitto test paw pressure test meter 鼠爪压力测量仪

  • plethysmometer, paw volume meter or paw edema meter鼠爪肿胀测量仪

  • rodent pincher test analgesia meter 钳式测痛仪

  • grip strength meter mice and rats 抓力测量仪


型号:2390型+2500型+520mr型+2450型+2200型


电子触觉阈疼痛阈测量仪机械痛阈测量仪von frey系统,简单易用。用来替代传统的von frey hairs纤毛机械刺激针von frey hairs.不仅可以von frey test测试机械痛阈或触觉阈测量,还可以测试疼痛阈值。它使研究者可以自动记录机械痛阈和触觉阈测量。操作简单,精确,设备紧凑。


电子von frey测痛仪的主要特点:

ø 适用mri探针

ø 单体内可插入三个探针

ø lcd 显示屏 (floating or last max. & minimum) 

ø 硬枪头能达 800 gr. 

ø “supertips™” 15 65gr. 

ø 适用1k探针

ø 电子微处理器0.1gr插入式探针

ø 可选的模拟输出线

ø 吸头可根据情况定制

ø 具有测量、存储和显示功能,免除了手算的繁琐。

ø 可以预设和选择最大限额,能精确到1g当到预设的限额时,警示灯会通知使用人员

ø 实验简便:选择合适的原件放在探针上,插进实验对象,根据实验对象的反应,仪器就能快速的显示出结果并储存。

ø 作为核心原件的内置传感器固定在元件上,并和电子系统相连,以便记录数据。所有的电子测痛仪已在出厂前校准完毕,不再需要购买任何的校准设备。


鼠爪压力测痛仪 randall&selitto测试,通过逐步提高作用于动物爪子上的机械压力,逼近动物的疼痛阈限,测量并记录动物产生逃避反应时的瞬间最大压力,以测定动物机械钝痛的痛觉阈限。


与热痛不同,鼠爪压力疼痛测痛用于机械压痛和钝痛的痛觉测量,常用于辨别左右爪不同的痛觉反应,多涉及脊髓神经过程,人工辨别动物缩腿反应,并用踏板控制马达的起止。


鼠爪压力疼痛测试仪的主要特点: 

ø 适用于大鼠和小鼠

ø 精确度为0.1克,最大压力400

ø 数字显示功能

ø 配置脚踏控制器

ø rs-232输出


爪体积测量仪用来衡量消炎药的有效性。使用时,讲大鼠、小鼠的爪子浸入含有特殊细胞的水中由于浸泡水的压力发生了变化。压力的变化会被校准,并显示在特殊的电子监视器上。这种检测形式可以消除由于重复浸入发生导电性的改变而产生的改变,这种情况在类似的其他仪器上发现过。测试结果直接显示在lcd上(大鼠精确到0.01毫升、小鼠精确到0.001毫升)。无论是用电池还是用9v12v的适配器,该设备表现稳定,操作安全

 

鼠爪肿胀测定仪的主要特点: 

ø 无需润湿液,可消除由于重复浸入发生导电性的改变而产生的体积误差 

ø 配备90°角的全透明亚克力操作支架,可进行清晰方便

ø 维护方便,不需要特殊的护理液

ø 数据准确,不需要每次使用校准,每年仅需校正一次

ø 具有内置电源,实现停电不间断操作

ø 带lcd显示器,读书方便

ø 体积精确度:0.01ml(大鼠)0.001ml(小鼠)


鼠抓力测量仪可用于小鼠或大鼠系统测试的使大鼠或小鼠释放的抓力。常用于药物、毒物、肌肉松弛药、衰老、神经损伤对肌力的影响。将大鼠或小鼠置于有机玻璃平台上,在抓力吊架前面。啮齿动物会本能地抓取任何东西,以尝试去停止这种被动的反向运动这将会持续抓吊台,直到牵力克服了抓力为止。动物失去其抓力后,力峰值前级放大器会自动地储存峰值的抓力,并显示在液晶板上。


大小鼠抓力测量仪的主要特点

ø 拉力传感器最大力度值≥1500g 

ø 最大力可允许超过数值≥150g

ø 读数精度为0.1g

ø 配备有专用基座、金属套杆和传感器hub

ø 配大小鼠网格和t形杆

ø 阳极电镀处理的面板,并配备有固定吸盘

ø 配备36g砝码校准模块

ø 数据采集器自带电源,可供数据采集器时间≥250小时

ø 带clear清零键,使用方便


  our newest addition to our analgesia line can perform the electronic von frey, digital randall selitto, plethysmometer and grip strength meter test and rodent pincher with one electronic system.

  order any one of the test systems complete and the only additional item(s) needed are the individual modules to perform each test.

  electronics has up to three inputs allowing users to perform four very different tests with one electronic system when studies call for doing so.

  all data is stored and displayed in the electronics supplied.

  part# 2650 stand and sling sold separately


部分参考文献:

 

[html] an electronic pressure-meter nociception paw test for mice

tm cunhawa verri jr, gg vivancos… - brazilian journal of , 2004 - scielo brasil

... an inflammatory process and sensitized the paws of mice with different doses of carrageenin
and prostaglandin e 2 (pge 2 ... consisted of a hand-held force transducer fitted with a 0.5 mm
2 polypropylene tip (electronic von frey anesthesiometer, iitc inc., life ...

 

[html] pharmacological characterisation of a rat model of incisional pain

gt whiteside, j harrison, j boulet… - british journal of , 2004 - wiley online library

... pharma, neuropharmacology, 6 cedar brook drive, cranbury, nj 08512, usa e-mail: garth ... issue
published online: 2 feb 2009; article first published online: 2 feb 2009; ... previously described
in this model: tactile allodynia using an automated electronic von frey (iitc, ca, usa ...

 

pharmacological characterization of the chronic constriction injury model of neuropathic pain

j de vry, kuhl, p franken-kunkel, g eckel - european journal of , 2004 - elsevier

... 4 december 2003 revised 1 march 2004 accepted 25 march 2004 available online 10 may
2004. abstract. ... mechanical allodynia was measured by means of a pressure transducer (electronic
von frey anaesthesiometer, iitc-life science instruments, woodland hills, ca). ...

 

selective activation of cannabinoid cb2 receptors suppresses neuropathic nociception induced by treatment with the chemotherapeutic agent paclitaxel in rats

ej rahn, am zvonok, ga thakur, ad khanolkar… … of pharmacology and , 2008 - aspet

... e-mail: ahohmann{at}uga.edu. next section. abstract. ... mechanical withdrawal thresholds were
assessed using a digital electronic von frey anesthesiometer (iitc model alemo 2290-4; iitc
life sciences inc., woodland hills, ca) equipped with a rigid tip. ...

 

pharmacological and pharmacokinetic characterization of the cannabinoid receptor 2 agonist, gw405833, utilizing rodent models of acute and chronic pain, anxiety, 

kj valenzano, l tafesse, g lee, je harrison… , 2005 - elsevier

... 2004 revised 26 november 2004 accepted 10 december 2004 available online 19 february ...
the marble-burying behavior model of anxiety (njung'e and handley, 1990 ... noxious tactile stimulus
(vwt) were determined using an automated electronic von frey apparatus (iitc ...

 

taurine replacement attenuates hyperalgesia and abnormal calcium signaling in sensory neurons of stz-d rats

f li, ig obrosova, o abatan, d tian… - american journal of , 2005 - am physiological soc

... digital sensory ncv (sncv) was recorded in the digital nerve to the second toe by stimulating
with a square ... by quantifying the withdrawal threshold of the hindpaw in response to mechanical
stimulation using a von frey anesthesiometer (model 2290c; iitc life science ...

 

activation of presynaptic nmda receptors coupled to nav1. 8-resistant sodium channel c-fibers causes retrograde mechanical nociceptor sensitization

ca parada, gg vivancos, ch tambeli… - proceedings of the , 2003 - national acad sciences

... intrathecal administration of prostaglandin e 2 (pge 2 ), glutamate, and nmda causes a bilateral
long-lasting mechanical paw hypernociception ... reflex with a hand-held force transducer adapted
with a 0.5-mm 2 polypropylene tip (electronic von frey hair; iitc life science ...

 

the use of an electronic von frey device for evaluation of sensory threshold in neurologically normal dogs and those with acute spinal cord injury

sa moore, bf hettlich, a waln - the veterinary journal, 2013 - elsevier

... accepted 3 november 2012 available online 13 december 2012. abstract. the ...
examination. von frey device. the electronic von frey device (iitc life science)
consisted of a load cell, handle, recording device and tip (fig. 1 ...

 

reproducibility of electronic von frey and von frey monofilaments testing

b tena, b escobar, mj arguis, c cantero… - the clinical journal , 2012 - journals.lww.com

... reprints: beatriz tena, md, hospital clinic, c/villarroel 170, 08036 barcelona, spain (e-mail:
btena@clinic.ub.es ... pain threshold was subsequently determined using a pressure algometer,
the electronic von frey (electronic von frey anesthesiometer iitc). ...

 

trka and pkc-epsilon in thermal burninduced mechanical hyperalgesia in the rat

gj summer, ka puntillo, c miaskowski, oa dina… - the journal of , 2006 - elsevier

... received 5 december 2005 revised 12 april 2006 accepted 12 april 2006 available online
6 december ... threshold in animals that underwent a plantar surface burn was assessed using an
electronic von frey (evf) model 1601ce anesthesiometer (iitc life science ...



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